The Neediest Cases: Emerging From a Bleak Life to Become Fabulous Phil





For years, Phillip Johnson was caught in what seemed like an endless trench of bad luck. He was fired from a job, experienced intensifying psychological problems, lost his apartment and spent time in homeless shelters. At one point, he was hospitalized after overdosing on an antipsychotic drug.




“I had a rough road,” he said.


Since his hospital stay two years ago, and despite setbacks, Mr. Johnson, 27, has been getting his life on track. At Brooklyn Community Services, where he goes for daily counseling and therapy, everybody knows him as Fabulous Phil.


“Phillip is a light, the way he evokes happiness in other people,” his former caseworker, Teresa O’Brien, said. “Phillip’s character led directly to his nickname.”


About six months ago, with Ms. O’Brien’s help, Mr. Johnson started an event: Fabulous Phil Friday Dance Party Fridays.


One recent afternoon at the agency, 30 clients and a few counselors were eating cake, drinking soft drinks and juice, and grooving for 45 minutes to Jay-Z and Drake pulsating from a boom box.


Mr. Johnson’s voice rose with excitement when he talked about the party. Clients and counselors, he said, “enjoy themselves.”


“They connect more; they communicate more,” he continued. “Everybody is celebrating and laughing.”


The leadership Mr. Johnson now displays seems to be a far cry from the excruciatingly introverted person he was.


As an only child living with his single mother in public housing in Bedford-Stuyvesant, Brooklyn, he said, he tended to isolate himself. “A lot of kids my age would say, ‘Come outside,’ but I would always stay in my room,” he said. He occupied himself by writing comic books or reading them, his favorites being Batman and Spiderman because, he said, “they were heroes who saved the day.”


After graduating from high school in 2003, he worked odd jobs until 2006, when he took a full-time position at a food court at La Guardia Airport, where he helped to clean up. The steady paycheck allowed him to leave his mother’s apartment and rent a room in Queens.


But the depression and bleak moods that had shadowed him throughout middle and high school asserted themselves.


“My thinking got confused,” he said. “Racing thoughts through my mind. Disorganized thoughts. I had a hard time focusing on one thing.”


In 2008, after two years on the job, Mr. Johnson was fired for loud and inappropriate behavior, and for being “unpredictable,” he said. The boss said he needed counseling. He moved back in with his mother, and in 2009 entered a program at an outpatient addiction treatment service, Bridge Back to Life. It was there, he said, that he received a diagnosis of schizophrenia and help with his depression and marijuana use.


But one evening in May 2010, he had a bout with insomnia.


He realized the antipsychotic medication he had been prescribed, Risperdal, made him feel tired, he said, so he took 12 of the pills, rather than his usual dosage of two pills twice a day. When 12 did not work, he took 6 more.


“The next morning when I woke up, it was hard for me to breathe,” he said.


He called an ambulance, which took to Woodhull Hospital. He was released after about a month.


Not long after, he returned to his mother’s apartment, but by February 2011, they both decided he should leave, and he relocated to a homeless shelter in East New York, where, he said, eight other people were crammed into his cubicle and there were “bedbugs, people lying in your bed, breaking into your locker to steal your stuff.”


In late spring 2011, he found a room for rent in Manhattan, but by Thanksgiving he was hospitalized again. Another stint in a shelter followed in April, when his building was sold.


Finally, in July, Mr. Johnson moved to supported housing on Staten Island, where he lives with a roommate. His monthly $900 Social Security disability check is sent to the residence, which deducts $600 for rent and gives him $175 in spending money; he has breakfast and lunch at the Brooklyn agency. To assist Mr. Johnson with unexpected expenses, a grant of $550 through The New York Times Neediest Cases Fund went to buy him a bed and pay a Medicare prescription plan fee for three months.


“I was so happy I have a bed to sleep on,” he said about the replacement for an air mattress. “When I have a long day, I have a bed to lay in, and I feel good about that.”


Mr. Johnson’s goals include getting his driver’s license — “I already have a learner’s permit,” he said, proudly — finishing his program at the agency, and then entering an apprenticeship program to become a plumber, carpenter or mechanic.


But seeing how his peers have benefited from Fabulous Phil Fridays has made him vow to remain involved with people dealing with mental illnesses or substance abuse.


He was asked at the party: Might he be like the comic-book heroes he loves? A smile spread across his face. He seemed to think so.


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A John Lautner-designed home in L.A.









Known for his forward-thinking engineering, architect John Lautner designed the Foster Carling house with a retractable wall of glass separating the outdoor part of the swimming pool from an interior portion in the living room. External steel beams support the hexagonal living space, which is free of internal columns.


Location: 7144 Hockey Trail, Los Angeles 90068


Asking price: $2.995 million





Year built: 1950


House size: Two bedrooms, two bathrooms, 1,999 square feet


Lot size: 16,002 square feet


Features: Redwood planking, raised fireplace, polished concrete floors, built-in furniture, bar, basement, alarm system, carport, skyline views.


About the area: In the third quarter, 86 single-family homes sold in the 90068 ZIP Code at a median price of $930,000, according to DataQuick. That was a 3.8% price increase from the third quarter last year.


Agent: John Galich, Rodeo Realty, (310) 461-0468


Lauren Beale


To submit a candidate for Home of the Week, send high-resolution color photos on a CD, written permission from the photographer to publish the images and a description of the house to Lauren Beale, Business, Los Angeles Times, 202 W. 1st St., Los Angeles, CA 90012. Send questions to homeoftheweek@latimes.com.





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Veteran L.A. County sheriff's deputy charged with murder









After spending much of his life putting people behind bars, a veteran L.A. County sheriff's deputy stood in handcuffs Thursday, charged with gunning down a former neighbor who apparently got into a fight with his son.


Francisco Gamez, 41, is accused of shooting Armando "Cookie" Casillas, a well-known figure in his blue-collar neighborhood in Sylmar.


Gamez was off duty, sitting in his car, when he allegedly fired two shots on the night of June 17, killing Casillas and narrowly missing a second man, prosecutors said.





Gamez, a 17-year veteran who worked as a detective in West Hollywood, was allegedly furious over a fight between his 20-year-old son and Casillas, 38, prosecutors said. The younger Gamez had called his father to the scene, authorities said.


Casillas was later found by relatives lying near his home, and died later at Providence Holy Cross Medical Center.


Gamez was removed from duty in July after witnesses and evidence tied the detective to the slaying, authorities said. He was arrested Wednesday and led handcuffed from his San Fernando home by his former co-workers.


On Thursday he was formally charged with murder, attempted murder and discharging a firearm from an occupied vehicle. Gamez could face 75 years to life in prison if convicted of all charges.


In court, where he stood handcuffed in a plexiglass cage, sheriff's deputies peeked into the room to gawk at their former colleague. Sheriff Lee Baca described the whole thing as "deeply disturbing."


Gamez is being held on $4-million bail.


On Beaver Street in Sylmar, where the shooting occurred, Casillas' photo sat in a frame in the midst of a makeshift memorial, along with a cross and a potted plant with U.S. and Mexican flags and candles.


"He was a sweetheart, and very generous," said Patsy Telles-Cabrera, who lived across the street from Casillas for years. "He would check in on my parents." She left a box of chocolates at the growing shrine.


"It never should have happened," said one neighbor. "This is a family neighborhood."


sam.quinones@latimes.com


richard.winton@latimes.com


Times staff writer Wesley Lowery contributed to this report.





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Analysis: New Microsoft mantra after Sinofsky – teamwork
















SEATTLE/SAN FRANCISCO (Reuters) – The sudden departure of powerful Windows boss Steven Sinofsky this week is the first step in a plan by CEO Steve Ballmer to remodel Microsoft Corp as a much more integrated operation in an attempt to take on Apple Inc and Google Inc at their own game.


After nearly 13 years at the helm of the world’s largest software maker, which just launched its first own-brand computer, sources inside the company say Sinofsky‘s departure signals Ballmer‘s new-found focus on co-operation between its self-sufficient – and sometimes warring – units.













“What I’m hearing over and over is collaboration and horizontal integration is the new mantra,” said one Microsoft insider, who asked not to be named. “They (top management) understand that, if they don’t move to a model where devices and software are more integrated across the entire Microsoft system, they are in a weak position.”


After floundering for most of the last decade, Microsoft is trying emulate the way Apple‘s software and hardware – such as iTunes and the iPhone – work perfectly together; or how Google‘s online suite from Web search to YouTube and Gmail are seamlessly joined.


Microsoft – which Ballmer rechristened as a “devices and services company” last month – has all the parts, analysts say, but has failed to put them together. Now Ballmer looks set to reshape the company to try to make that a reality.


“I certainly expect the org chart to look a lot different six months from now,” said Brad Silverberg, who ran the Windows unit during its massive growth spurt in the 1990s. “There will be attrition from Steven’s (Sinofsky’s) people and Steve Ballmer will have a chance to create a more harmonious organization.”


Ballmer replaced Sinofsky with two executives with a reputation for co-operation. The move marks the third time in the last few years that Ballmer has replaced a single unit head with two leaders sharing responsibilities.


“Sinofsky really centralized all the power under himself. We’ll see how it shakes out from here,” said one manager in the Windows unit.


More fundamental organizational shifts could be in the cards.


“A lot of things are up for grabs,” said David Smith at tech research firm Gartner. “How the management is structured – there could be more changes.”


NO ROOM FOR AN EMPIRE BUILDER


Sinofsky, a 23-year Microsoft veteran, built up a walled empire around his Windows unit.


His hard-charging but methodical style, which took on the name “Sinofskyization,” alienated other groups in the company, especially the Office unit, the other financial pillar of Microsoft‘s success.


“Steven is a brilliant guy who made tremendous contributions to Microsoft,” said Silverberg. “But he was also a polarizing guy and the antibodies ultimately caught up with him.”


The decision not to share the latest internal test versions of Windows 8 and keep the Surface tablet a secret until just before its announcement especially upset the Office group, which insiders say accounts for the lack of a fully featured Office suite on the Surface RT tablet.


“All good leaders create friction, but my guess is the cost of doing business with Sinofsky ended up outweighing the benefits,” said a former Microsoft staffer who saw Sinofsky operate at close quarters.


“If you work in Steven’s team, you love him,” said a former colleague who now works for a financial technology firm in Seattle. “If he’s outside of your team? That’s where his reputation of being hard to work with came from.”


Ballmer has made it clear that executives have to work together better. Next year, top managers will get bonuses based on company-wide performance, not just their own unit, which Ballmer hopes will lead to “deeper cross-organization collaboration.”


But there is no guarantee Ballmer can radically redirect almost four decades of culture at Microsoft – which he is partly responsible for – that gave Windows primacy and intentionally pitted teams against one another to get the best results.


Nothing will change without new leaders from outside the company, said Trip Chowdhry, managing director at Global Equities Research.


Microsoft is clinging to the past and they keep bringing in the people from the past. This is a fundamental flaw in the logic,” Chowdhry said.


CEO THRONE


Despite urging collaboration, Ballmer – a 32-year Microsoft veteran who took over as CEO from Bill Gates in 2000 – does not let any junior executive get too close to challenging his authority.


Sinofsky, widely touted as Ballmer’s successor for the past three years, was just the latest in a line of would-be CEOs. Over the last five years alone, Ballmer has seen off a clutch of rising stars that were discussed as potential leaders.


Windows and online head Kevin Johnson went to run Juniper Networks Inc, Office chief Stephen Elop went to lead phone maker Nokia, while Ray Ozzie – the software guru Bill Gates designated as Microsoft‘s big-picture thinker – left to start his own project.


“They’ve gone through quite a bit of senior management talent in the past few years. The bench is not what it used to be,” said Smith at Gartner. “The overall management structure, career path, replacements, succession planning – a lot of that is an issue for Microsoft.”


Ballmer’s promotion of Julie Larson-Green and Tami Reller to jointly fill Sinofsky’s role may only be temporary, Microsoft-watchers say.


“The question is what comes after, like in the next three years,” said Rob Helm at Directions on Microsoft, an independent firm that advises business customers on how to deal with Microsoft.


(Reporting By Bill Rigby in Seattle and Alexei Oreskovic in San Francisco.; Editing by Edward Tobin, Martin Howell and Andre Grenon)


Tech News Headlines – Yahoo! News



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Jesse & Joy take 4 Latin Grammys, Juanes wins too

LAS VEGAS (AP) — As Colombian rockero Juanes took home the best album award, Mexican brother-sister duo Jesse & Joy and their pop hit "Corre!" ran away with four awards at the 13th Annual Latin Grammys.

Hosted by actors Cristian De La Fuente and Lucero, Thursday night's event attracted stars from across the world and from dozens of Latin musical genres to the Mandalay Bay Events Center. Just like at a big family party, new faces shared the spotlight with older generations, and traditional styles mixed with electronica and Vegas dancers on stage.

Traditional Mexico met Las Vegas in a colorful number featuring Oaxaca native Lila Downs, Afro-Colombian singer Toto la Momposina and dancers in regional costumes, Carnival masques and skeleton makeup.

"What a great joy. Thank God, and all the fans," Juanes said as he dragged Dominican mereguero Juan Luis Guerra, who produced "MTV Unplugged," to the stage to accept the mini-gramaphone for best album at the close of the ceremony.

The winner for best new artist, the Mexican DJ trio 3ball MTY, threw down beats with America Sierra and Sky Blu of LMFAO. Pitbull performed "Don't Stop the Party" with dancers in gold spangled bikinis and hot pants. Juanes jammed with legendary guitarist Carlos Santana.

Michel Telo, the Brazilian sertanejo or country music singer, performed his hit, "Ai si eu te pego,"with Blue Man Group. Bachata heartthrob Prince Royce sang with veteran Mexican singer-songwriter Joan Sebastian. But the applause was also strong for the 1980s hit, "Yo No Te Pido la Luna," a duet between Spaniard Sergio Dalma and Mexican singer Daniela Romo, sporting a short silver hairdo following her bout with breast cancer.

Jesse & Joy also won for best contemporary pop vocal album for "Con Quien se Queda el Perro" and best short video for "Me voy."

"Thanks to people like Juanes and Juan Luis Guerro who have inspired us. Love and peace," Jesse said.

Guerra, who came into the ceremony as the leading nominee with six bids, won producer of the year for Juanes' album "MTV Unplugged."

Guerra performed "En el Cielo No Hay Hospital," which brought the audience to its feet to dance, and for a standing ovation.

Puerto Rican reggaeton singer Don Omar and Uruguayan alt rockers Cuarteto de Nos won two Latin Grammys each.

Downs won best folkloric album for "Pecados y Milagros." Colombian singer Fonseca won for best tropical fusion album, and Los Tucanes de Tijuana won best norteno album for "365 Dias," the narco-corrido band's 32nd album.

Milly Quezada brought home two statuettes, including best contemporary tropical album for "Aqui estoy yo."

"Long live merengue! Long live the Dominican Republic!" she said as she accepted the award. She also thanked Guerra, who helped produce the album.

Cuban-American jazz trumpeter Arturo Sandoval won three Latin Grammys, two for "Dear Diz (Every Day I Think of You)," but said these awards was just exciting as his first.

"The emotion is the same because one puts the same effort into each recording and the fact that the work is received well and respected by the public is very satisfying," he said.

The Latin Grammy celebration kicked off Wednesday with a tribute to Person of the Year winner, Caetano Veloso, one of the founders of the Tropicalismo movement.

The Brazilian singer, composer and activist sang in Spanish and Portuguese before Pitbull and Sensato closed with "Crazy People."

The event was broadcast live on Univision.

Interactive: http://hosted.ap.org/interactives/2012/latin-grammys/

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For Alzheimer’s, Detection Advances Outpace Treatment Options


Joshua Lott for The New York Times


Awilda Jimenez got a scan for Alzheimer’s after she started forgetting things. It was positive.







When Awilda Jimenez started forgetting things last year, her husband, Edwin, felt a shiver of dread. Her mother had developed Alzheimer’s in her 50s. Could his wife, 61, have it, too?




He learned there was a new brain scan to diagnose the disease and nervously agreed to get her one, secretly hoping it would lay his fears to rest. In June, his wife became what her doctor says is the first private patient in Arizona to have the test.


“The scan was floridly positive,” said her doctor, Adam S. Fleisher, director of brain imaging at the Banner Alzheimer’s Institute in Phoenix.


The Jimenezes have struggled ever since to deal with this devastating news. They are confronting a problem of the new era of Alzheimer’s research: The ability to detect the disease has leapt far ahead of treatments. There are none that can stop or even significantly slow the inexorable progression to dementia and death.


Families like the Jimenezes, with no good options, can only ask: Should they live their lives differently, get their affairs in order, join a clinical trial of an experimental drug?


“I was hoping the scan would be negative,” Mr. Jimenez said. “When I found out it was positive, my heart sank.”


The new brain scan technology, which went on the market in June, is spreading fast. There are already more than 300 hospitals and imaging centers, located in most major metropolitan areas, that are ready to perform the scans, according to Eli Lilly, which sells the tracer used to mark plaque for the scan.


The scans show plaques in the brain — barnaclelike clumps of protein, beta amyloid — that, together with dementia, are the defining feature of Alzheimer’s disease. Those who have dementia but do not have excessive plaques do not have Alzheimer’s. It is no longer necessary to wait until the person dies and has an autopsy to learn if the brain was studded with plaques.


Many insurers, including Medicare, will not yet pay for the new scans, which cost several thousand dollars. And getting one comes with serious risks. While federal law prevents insurers and employers from discriminating based on genetic tests, it does not apply to scans. People with brain plaques can be denied long-term care insurance.


The Food and Drug Administration, worried about interpretations of the scans, has required something new: Doctors must take a test showing they can read them accurately before they begin doing them. So far, 700 doctors have qualified, according to Eli Lilly. Other kinds of diagnostic scans have no such requirement.


In another unusual feature, the F.D.A. requires that radiologists not be told anything about the patient. They are generally trained to incorporate clinical information into their interpretation of other types of scans, said Dr. R. Dwaine Rieves, director of the drug agency’s Division of Medical Imaging Products.


But in this case, clinical information may lead radiologists to inadvertently shade their reports to coincide with what doctors suspect is the underlying disease. With Alzheimer’s, Dr. Rieves said, “clinical impressions have been misleading.”


“This is a big change in the world of image interpretation,” he said.


Like some other Alzheimer’s experts, Dr. Fleisher used the amyloid scan for several years as part of a research study that led to its F.D.A. approval. Subjects were not told what the scans showed. Now, with the scan on the market, the rules have changed.


Dr. Fleisher’s first patient was Mrs. Jimenez. Her husband, the family breadwinner, had lost his job as a computer consultant when the couple moved from New York to Arizona to take care of Mrs. Jimenez’s mother. Paying several thousand dollars for a scan was out of the question. But Dr. Fleisher found a radiologist, Dr. Mantej Singh Sra of Sun Radiology, who was so eager to get into the business that he agreed to do Mrs. Jimenez’s scan free. His plan was to be the first in Arizona to do a scan, and advertise it.


After Dr. Sra did the scan, the Jimenezes returned to Dr. Fleisher to learn the result.


Dr. Fleisher, sad to see so much plaque in Mrs. Jimenez’s brain, referred her to a psychiatrist to help with anxiety and suggested she enter clinical trials of experimental drugs.


But Mr. Jimenez did not like that idea. He worried about unexpected side effects.


“Tempting as it is, where do you draw the line?” he asks. “At what point do you take a risk with a loved one?”


At Mount Sinai Medical Center in New York, Dr. Samuel E. Gandy found that his patients — mostly affluent — were unfazed by the medical center’s $3,750 price for the scan. He has been ordering at least one a week for people with symptoms ambiguous enough to suggest the possibility of brain plaques.


Most of his patients want their names kept confidential, fearing an inability to get long-term care insurance, or just wanting privacy.


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JPMorgan's California energy dealings draw more fire









State and federal energy regulators moved on two fronts against the giant investment bank JPMorgan Chase & Co. over its dealings in the California electricity market.


On Wednesday, the Federal Energy Regulatory Commission hit Morgan's electricity-trading unit with one of the most stringent penalties in its arsenal, barring it from selling electricity in California's auction-based market for six months starting in April.


The ruling, which may deprive Morgan of millions of dollars in profits in California, stemmed from FERC's conclusion that JPMorgan Ventures Energy Corp. had misled the agency in its investigation of alleged overcharges to the California Independent System Operator, which runs much of the state's wholesale power grid.








Meanwhile, the ISO moved Thursday to stop Morgan from blocking the upgrade of two Huntington Beach power plants considered key to keeping air conditioners humming next summer in Southern California. Morgan could not be reached for comment.


The operator of California's far-flung power grid filed a petition with federal regulators, accusing Morgan of raising legal obstacles to getting the plants working in time to avoid possible brownouts and rolling blackouts when the temperatures climb.


The shoreline facilities, currently not in use, are needed to help make up for the loss of more than 2,000 megawatts of power caused by the shutdown for safety reasons of both reactors at Southern California Edison's San Onofre Nuclear Generating Station.


Several power plants in Huntington Beach are owned by AES Corp. Two of them currently supply power to Morgan. But it is two other plants there, currently not operating, that the state wants to upgrade.


But the ISO says AES is balking, saying Morgan doesn't want to go along with the upgrade. The state is trying to force Morgan and AES to go ahead.


Grid operators want FERC to rule that JPMorgan's consent is not needed to retrofit the Huntington Beach power plants. The retrofit is essential to maintain sufficiently high voltage in transmission lines to meet peak summertime demand.


"The inability to resolve the consent issue in time to allow construction to commence in early 2013 could leave Southern California exposed to reliance on a widespread load-shedding scheme in the summer of 2013," state officials warned the commission.


The state agency's petition was submitted one day after federal energy regulators suspended JPMorgan Ventures after finding that the energy firm had provided false data and omitted important information during the federal investigation. It is reviewing state allegations that the firm hit utilities with excessive charges of as much as $73 million in 2011 and the beginning of this year.


Of that, the state has recovered about $20 million in overcharges, said Stephanie McCorkle, a spokeswoman for the state power grid operator.


The suspension was ordered to begin April 13 of next year. The delay was aimed at giving the grid managers sufficient time to contract for new power deliveries to ensure the lights stay on across the state.


JPMorgan Ventures is one of several energy-trading firms that buy and sell power nationally and play a key role in delivering electricity to states when demand is high and supplies are short.


The firm fought the suspension and told the commission in October that the company's actions were "inadvertent mistakes" and said that suspending its trading authority would be an "unjustified reaction to unintentional, good-faith mistakes, misunderstandings and miscommunications."


marc.lifsher@latimes.com





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L.A. County sheriff's deputy held in fatal off-duty shooting









A veteran Los Angeles County sheriff's deputy was arrested Wednesday for allegedly shooting and killing a man in Sylmar while off-duty in June, authorities said.

The deputy, Francisco Gamez, 41, has been with the department for 17 years and was last working as a station detective in West Hollywood.

Law enforcement sources told The Times that the deputy's son got into a dispute with another person. The son, they said, called his father to the scene. The deputy allegedly drove up soon after and exchanged words before opening fire from inside his car, striking one man, the sources said.





He then allegedly drove a short distance before shooting at a second person, added the sources, who asked for anonymity because the investigation is ongoing.

That person was not injured, according to authorities.

The other victim, Armando Casillas, 38, was taken to a hospital, where he was pronounced dead from a gunshot wound to the chest just before midnight on June 17.


FOR THE RECORD:
An earlier version of this article misspelled the victim's first name as Armondo.

Neighbors said Gamez and Casillas lived a block apart.

In August, a person who identified himself as the victim's brother commented on the website of the Los Angeles Times, saying he suspected a deputy was responsible.

"We think he is a L.A. COUNTY SHERIFF," the comment stated. "The reason we think he is a Sheriff is that he shouted to my Brother "L.A. COUNTY SHERIFF WHERE YOU FROM" as if the sheriff was in a gang."

The person who wrote the comment could not be reached Wednesday evening.

At the time of the killing, authorities said the victim got into an argument with an unknown person. At some point, the other person left the area only to return and shoot Casillas in a drive-by, authorities said then. Now they are saying that the shooter was not the same person who initially got into the argument.

LAPD officers arrested Gamez on suspicion of murder, attempted murder and use of a firearm in the commission of a felony. He was booked into the LAPD's 77th Street station Wednesday in lieu of $4-million bail, officials said. He has not been charged.

Casillas' sister said that the family was thankful for the arrest, but that they were not prepared to discuss the events that led to the fatal shooting.

In a statement, Sheriff Lee Baca called the incident "deeply disturbing."

His spokesman Steve Whitmore said the department placed Gamez on leave July 3 after learning from the LAPD about the investigation.

"He's been stripped of all law enforcement power," Whitmore said. "It casts a pall over the scores and scores of deputy sheriffs that every day do their job."

robert.faturechi@latimes.com

richard.winton@latimes.com

Times staff writer Andrew Blankstein contributed to this report.





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Erdrich wins her first National Book Award

NEW YORK (AP) — The National Book Awards honored both longtime writers and new authors, from Louise Erdrich for "The Round House" to Katherine Boo for her debut work, "Beyond the Beautiful Forevers."

Erdrich, 58, has been a published and highly regarded author for nearly 30 years but had never won a National Book Award until being cited Wednesday for her story, the second of a planned trilogy, about an Ojibwe boy and his quest to avenge his mother's rape. A clearly delighted and surprised Erdrich, who's part Ojibwe, spoke in her tribal tongue and then switched to English as she dedicated her fiction award to "the grace and endurance of native people."

The works of two other winners also centered on young boys — Boo's for nonfiction, and William Alexander's fantasy "Goblin Secrets," for young people's literature. David Ferry won for poetry.

Boo's book, set in a Mumbai slum, is the story of a boy and his harsh and illuminating education in the consequences of crime or perceived crime. The author, a Pulitzer Prize-winning journalist currently on staff with The New Yorker, said she was grateful for the chance to live in a world she "didn't know" and for the chance to tell the stories of those otherwise ignored. She praised a fellow nominee and fellow Pulitzer-winning reporter, the late Anthony Shadid, for also believing in stories of those without fame or power.

Boo was chosen from one of the strongest lists of nonfiction books in memory, from the fourth volume of Robert Caro's Lyndon Johnson series to Shadid's memoir "House of Stone." Finalists in fiction, which in recent years favored lesser known writers, included such established names as Dave Eggers and Junot Diaz. Publishers have been concerned that the National Book Awards have become too insular and are considering changes, including expanding the pool of judges beyond writers.

Winners, chosen by panels of their peers, each will receive $10,000.Judges looked through nearly 1,300 books.

Ferry is a year older than one of the night's honorary recipients, Elmore Leonard. Ferry, 88, won for "Bewilderment: New Poems and Translations," a showcase for his versatile style. He fought back tears as he confided that he thought there was a chance for winning because he "was so much older" than the other nominees. Attempting to find poetry in victory, he called the award a "pre-posthumous" honor.

Alexander quoted fellow fantasy writer Ursula K. Le Guin in highlighting the importance of stories for shaping kids' imaginations and making the world a larger place than the one they live in.

"We have to remember that," Alexander said.

The ceremony was hosted by commentator-performer Faith Salie and went smoothly even though Superstorm Sandy badly damaged the offices of the award's organizer, the National Book Foundation, whose staffers had to work with limited telephone and mail access.

Honorary prizes were given to Leonard and New York Times publisher and chairman Arthur O. Sulzberger Jr.

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Alzheimer’s Tied to Mutation Harming Immune Response





Alzheimer’s researchers and drug companies have for years concentrated on one hallmark of Alzheimer’s disease: the production of toxic shards of a protein that accumulate in plaques on the brain.




But now, in a surprising coincidence, two groups of researchers working from entirely different starting points have converged on a mutated gene involved in another aspect of Alzheimer’s disease: the immune system’s role in protecting against the disease. The mutation is suspected of interfering with the brain’s ability to prevent the buildup of plaque.


The discovery, researchers say, provides clues to how and why the disease progresses. The gene, known as TREM2, is only the second found to increase Alzheimer’s risk substantially in older people.


“It points very specifically to a potential metabolic pathway that you could intervene in to change the course of Alzheimer’s disease,” said William Thies, chief medical and scientific officer of the Alzheimer’s Association.


Much work remains to be done before scientists understand precisely how the newly discovered gene mutation leads to Alzheimer’s, but already there are some indications from studies in mice. When the gene is not mutated, white blood cells in the brain spring into action, gobbling up and eliminating the plaque-forming toxic protein, beta amyloid. As a result, Alzheimer’s can be staved off or averted.


But when the gene is mutated, the brain’s white blood cells are hobbled, making them less effective in their attack on beta amyloid.


People with the mutated gene have a threefold to fivefold increase in the likelihood of developing Alzheimer’s disease in old age.


The intact gene, says John Hardy of University College London, “is a safety net.” And those with the mutation, he adds, “are living life without a safety net.” Dr. Hardy is lead author of one of the papers.


The discovery also suggests that a new type of drug could be developed to enhance the gene’s activity, perhaps allowing the brain’s white blood cells to do their work.


“The field is in desperate need of new therapeutic agents,” said Alison Goate, an Alzheimer’s researcher at Washington University in St. Louis who contributed data to Dr. Hardy’s study. “This will give us an alternative approach.”


The fact that two research groups converged on the same gene gives experts confidence in the findings. Both studies were published online Wednesday in The New England Journal of Medicine. “Together they make a good case that this really is an Alzheimer’s gene,” said Gerard Schellenberg, an Alzheimer’s researcher at the University of Pennsylvania who was not involved with the work.


The other gene found to raise the odds that a person will get Alzheimer’s, ApoE4, is much more common and confers about the same risk as the mutated version of TREM2. But it is still not clear why ApoE4, discovered in 1993, makes Alzheimer’s more likely.


Because the mutations in the newly discovered gene are rare, occurring in no more than 2 percent of Alzheimer’s patients, it makes no sense to start screening people for them, Dr. Thies said. Instead, the discovery provides new clues to the workings of Alzheimer’s disease.


To find the gene, a research group led by Dr. Kari Stefansson of deCODE Genetics of Iceland started with a simple question.


“We asked, ‘Can we find anything in the genome that separates those who are admitted to nursing homes before the age of 75 and those who are still living at home at 85?’ ” he said.


Scientists searched the genomes of 2,261 Icelanders and zeroed in on TREM2. Mutations in that gene were more common among people with Alzheimer’s, as well as those who did not have an Alzheimer’s diagnosis but who had memory problems and might be on their way to developing Alzheimer’s.


The researchers confirmed their results by looking for the gene in people with and without Alzheimer’s in populations studied at Emory University, as well as in Norway, the Netherlands and Germany.


The TREM2 connection surprised Dr. Stefansson. Although researchers have long noticed that the brain is inflamed in Alzheimer’s patients, he had dismissed inflammation as a major factor in the disease.


“I was of the opinion that the immune system would play a fairly small role, if any, in Alzheimer’s disease,” Dr. Stefansson said. “This discovery cured me of that bias.”


Meanwhile, Dr. Hardy and Rita Guerreiro at University College London, along with Andrew Singleton at the National Institute on Aging, were intrigued by a strange, rare disease. Only a few patients had been identified, but their symptoms were striking. They had crumbling bones and an unusual dementia, sclerosing leukoencephalopathy.


“It’s a weird disease,” Dr. Hardy said.


He saw one patient in her 30s whose brain disease manifested in sexually inappropriate behavior. Also, her bones kept breaking. The disease was caused by mutations that disabled both the copy of TREM2 that she had inherited from her mother and the one from her father.


Eventually the researchers searched for people who had a mutation in just one copy of TREM2. To their surprise, it turned out that these people were likely to have Alzheimer’s disease.


They then asked researchers around the world who had genetic data from people with and without Alzheimer’s to look for TREM2 mutations.


“Sure enough, they had good evidence,” Dr. Hardy said. The mutations occurred in one-half of 1 percent of the general population but in 1 to 2 percent of patients with Alzheimer’s disease.


“That is a big effect,” Dr. Hardy said.


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